The unrooted set covering connected subgraph problem differentiating between HIV envelope sequences
نویسندگان
چکیده
منابع مشابه
The unrooted set covering connected subgraph problem differentiating between HIV envelope sequences
This paper presents a novel application of operations research techniques to the analysis of HIV env gene sequences, aiming to identify key features that are possible vaccine targets. These targets are identified as being critical to the transmission of HIV by being present in early transmitted (founder) sequences and absent in later chronic sequences. Identifying the key features of env involv...
متن کاملDifferentiating founder and chronic HIV envelope sequences
Significant progress has been made in characterizing broadly neutralizing antibodies against the HIV envelope glycoprotein Env, but an effective vaccine has proven elusive. Vaccine development would be facilitated if common features of early founder virus required for transmission could be identified. Here we employ a combination of bioinformatic and operations research methods to determine the...
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ژورنال
عنوان ژورنال: European Journal of Operational Research
سال: 2016
ISSN: 0377-2217
DOI: 10.1016/j.ejor.2015.07.011